Experimental Glomerulonephritis Induced with the Major Antigen of Rat Kidney
Bibliographic record
Abstract
The major antigen of rat kidney (KMA) isolated in an immunochemically purified form was injected into homologous rats at 2-week intervals during 42 weeks. Circulating antibodies against KMA were constantly found in the sera of all immunized animals after 4 months of KMA treatment. Marked proteinuria accompanied by a significant increase in the serum γ-globulin level occurred only several months after the appearance of circulating antibodies. Histological examinations of the KMA-treated rat kidney revealed mild but definite glomerular lesions of the membranous, non-proliferative type. Rat γ-globulin was found as a mixed, linear and granular, deposit along the basement membranes and the mesangial regions. However, rat β1C-globulin was found as an exclusively granular deposit in the same areas, but more intensively in the mesangium. The acid elution of KMA-treated rat kidney contained γ-globulin which reacted with KMA. As compared with Edgington’s nephritogenic tubular antigen RTE-α5, KMA was found to be completely different. However, it was also localized exclusively in the proximal tubular cells. Its presence in normal rat serum and liver has been suggested as a source of autologous immunogens in the long-term development of an autoimmune complex nephritis in the rat.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.002 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".