Effect of Pressurization on Mechanical Properties of Mesenteric Small Arteries from Spontaneously Hypertensive Rats
Bibliographic record
Abstract
The mechanical properties of the wall of isolated perfused arterial segments of mesenteric small arteries from 17-week-old spontaneously hypertensive rats (SHR) and age-matched Wistar Kyoto rats (WKY) were investigated. Third-order branches of mesenteric arteries were mounted in a pressure myograph chamber and pressurized from 1 to 140 mm Hg. Under isobaric conditions, the outer diameter and the lumen of small arteries studied were smaller in SHR than in WKY, whereas media width, media cross-sectional area and media-lumen ratio were greater in SHR. Under passive conditions, the total change in internal and external diameter in response to increasing intravascular pressure was smaller in arteries from SHR. Incremental distensibility was significantly lower in arteries of SHR at intravascular pressures between 1 and 40 mm Hg, but was significantly greater between pressures of 40-100 mm Hg. Wall stress generated by intravascular pressure was significantly smaller in arteries from SHR. As a function of wall strain (under isometric conditions), stress and incremental elastic modulus were shifted to the left in SHR vessels. Under isobaric conditions or in relation to wall stress, the slope of elastic modulus was smaller in SHR. This decrease in elastic modulus may confer additional elasticity to the vascular wall of resistance arteries from SHR. The presence of a greater distensibility at physiological levels of intravascular pressure and decreased incremental elastic modulus indicates that the changes in the structure of small mesenteric arteries in SHR can be defined as the result of a combination of eutrophic and hypertrophic remodeling.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".