EEG analysis for estimation of duration and inter-event intervals of seizure-like events recorded in vivo from mice
Bibliographic record
Abstract
Rett syndrome is a neurodevelopmental disorder of the brain that affects females more often than males. Its cause is linked to the mutations within the gene encoding methyl CpG-binding protein 2 (MeCP2). Presently, there is little information regarding how the loss of MeCP2 affects brain activity. It has been documented that during awake but immobile state, the MeCP2 deficient mice exhibit spontaneous, rhythmic electroencephalogram (EEG) seizure-like events (SLEs) in the range of 6-9 Hz. In this study, we analyze the cortical EEG activity in female MeCP2-deficient mice over 24 hour recordings. Characterizing the SLE and inter-SLE durations by fitting to a gamma distribution we show similarity to previous in vivo epilepsy studies. These results suggest that the SLE and inter-SLE dynamics differ. More precisely, the SLE terminations appear to be a result of time-dependent mechanisms, whereas the inter-SLEs are a result of a random process.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".