Un canal sans pore ? La structure primaire d’un canal perméable aux protons enfin dévoilée
Bibliographic record
Abstract
930 canaux cationiques, la nature moleculaire des proteines responsables de ces conductances est demeuree longtemps obscure. Recemment, deux equipes (l’une japonaise et l’autre americaine) ont annonce le clonage d’un ADN complementaire (ADNc) d’une proteine ayant une haute homologie avec le domaine senseur de voltage des canaux ioniques dependants du voltage [5, 6]. L’equipe de Sasaki [5] a clone cette proteine, nommee mVSOP (membrane voltage sensor only protein), chez la souris. De leur cote, Ramsey et ses collaborateurs [6] sont arrives a la meme sequence chez l’hom-me et, par cons e q u e n t , ont nomme la proteine Hv1 (human v o l t a g e s e n s o r one). Dans ces deux etudes, la s e q u e n c e primaire de la proteine clonee est homologue au senseur d e v o l tage et ne c o n t i e n t a u c u n e autre region homologue a un pore de canal > Les canaux a protons actives par le voltage, ont ete identifies pour la premiere fois en 1982 dans les neurones d’escargots [1] et ont ete caracterises egalement dans les cellules epitheliales alveolaires, les macrophages, les granulocytes, les osteoclastes, les microglies [2] et, plus recemment, dans les fibroblastes cardiaques humains [3, 4]. Ces canaux jouent, entre autres, un role important dans la regulation de la production des anions superoxyde (O2-) durant le processus de la defense immunitaire, le remodelage osseux et, plus generalement, dans le controle du pH intracellulaire. Contrairement a d’autres NOUVELLE
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.001 | 0.004 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".