Does pharmacologically induced weight loss improve cardiovascular outcome? Sibutramine pharmacology and the cardiovascular system
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
The serotonin and noradrenaline re-uptake inhibitor, sibutramine, is a widely used anti-obesity drug that promotes weight loss by increasing satiety, although a mild increase in energy expenditure may also contribute. Noradrenaline re-uptake inhibition with sibutramine in peripheral tissues could theoretically exacerbate arterial hypertension through an increase in synaptic noradrenaline concentrations. This has led to a widespread perception that sibutramine contributes to hypertension and should not be used in patients at high risk of cardiovascular disease. However, neither published trials nor post hoc re-analysis of randomized trial data support this notion; the incidence of sustained blood pressure (BP) increase with sibutramine is not significantly different from control. Indeed, post-marketing surveillance data suggest a significant decrease in BP with sibutramine in obese hypertensives. The biological basis of this effect is underpinned by detailed consideration of adrenergic receptor pharmacology and confirmed by mechanistic studies.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it