Differential age‐related changes in motor unit properties between elbow flexors and extensors
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Bibliographic record
Abstract
AIM: Healthy adult ageing of the human neuromuscular system is comprised of changes that include atrophy, weakness and slowed movements with reduced spinal motor neurone output expressed by lower motor unit discharge rates (MUDRs). The latter observation has been obtained mostly from hand and lower limb muscles. The purpose was to determine the extent to which elbow flexor and extensor contractile properties, and MUDRs in six old (83 +/- 4 years) and six young (24 +/- 1 years) men were affected by age, and whether any adaptations were similar for both muscle groups. METHODS: Maximal isometric voluntary contraction (MVC), voluntary activation, twitch contractile properties, force-frequency relationship and MUDRs from sub-maximal to maximal intensities were assessed in the elbow flexors and extensors. RESULTS: Both flexor and extensor MVCs were significantly (P < 0.05) less (approximately 42% and approximately 46% respectively) in the old than in the young. Contractile speeds and the force-frequency relationship did not show any age-related differences (P > 0.05). For the elbow flexors contraction duration was approximately 139 ms and for the extensors it was approximately 127 ms for both age groups (P > 0.05). The mean MUDRs from 25% MVC to maximum were lower (approximately 10% to approximately 36%) in the old than in the young (P < 0.01). These age-related differences were larger for biceps (Cohen's d = 8.25) than triceps (Cohen's d = 4.79) brachii. CONCLUSION: Thus, at least for proximal upper limb muscles, mean maximal MUDR reductions with healthy adult ageing are muscle specific and not strongly related to contractile speed.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it