Bibliographic record
Abstract
Cyclin Dependent Kinase 1 (CDK1) is a key mitotic regulator that associates with Cyclin proteins to form active Cyclin-CDK1 complexes. The mitotic roles of Cyclin-CDK1 complexes are well understood, but the regulation and function of the meiotic Cyclin-CDK1 complexes remain largely unsolved. This research project explored the roles of Cyclin A-CDK1 and Cyclin B-CDK1 in Drosophila female meiosis. This study found that constitutive activation of Cyclin A-CDK1 causes defects such as chromosome missegregation (meiosis I and II) and abnormal spindle assembly (meiosis II), implying that Cyclin A must be degraded before anaphase I and II. This study also found that Cyclin B-CDK1 is required for maintenance of the metaphase I arrest, proper chromosome segregation (meiosis I and II), proper spindle assembly (meiosis II), repression of DNA replication, and completion of meiosis. The findings of this study also suggest that Cyclin B -CDK1 may promote Cyclin A degradation during meiosis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".