GENERATION OF IMMUNE RESPONSES IN EXPERIMENTAL ALLERGIC AIRWAY INFLAMMATION
Bibliographic record
Abstract
Allergic diseases, including asthma, result from airway inflammatory responses directed against ubiquitous antigens-allergens. The detailed immunological mechanisms underlying the development of allergy (allergic sensitization) have not been fully elucidated. Our understanding of the complexity of cellular interactions underlying allergic inflammation originates mainly, but not exclusively, from studies in experimental animal models. The studies presented in this thesis utilize experimental mouse models of anti-geninduced allergic airways inflammation in order to investigate 1) the events occurring during sensitization (primary immune responses) and following re-challenge (secondary immune responses) in two immunologically important sites: lungs and lymph nodes following experimental allergen (ovalbumin; OVA) exposure; 2) the role of the secondary lymphoid organs vs. lungs in elicitation of immune responses to allergen; 3) the importance of two major costimulatory pathways - CD28/B7 and ICOS/B7RP-1 - in the generation of allergic airways inflammation. Findings presented here indicate that introduction of antigen leads to vigorous T and B cell activation in the draining lymph nodes. Such activation translates into the acquisition of a Th2 phenotype, an important step in the generation of allergic sensitization. Considering the multitude of changes occurring in the draining lymph nodes, the importance of lymph nodes during sensitization was investigated in mice devoid of lymph nodes - Iymphotoxin (l deficient mice. The study demonstrated the absolute requirement of lymphoid organs, either lymph nodes or spleen in generating of Th2-type inflammatory responses. Finally, studies on CD28 and B7RP-1 deficient mice indicated that, whereas the CD28/B7 pathway is necessary for the establishment of allergic airway inflammation, the ICOSIB7RP-1 pathway is redundant. The data presented in this thesis identifies several important aspects by which the immune system generates efficient allergic airway inflammation. As we suspect that new-sensitization occurs after each exposure to allergens. information in this thesis may provide insights into novel therapeutic strategies.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.275 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".