Distinct Roles of Dendritic and B Cells in the Activation of Naive CD4 <sup>+</sup> T Cells
Bibliographic record
Abstract
ImmunotherapyVol. 4, No. 4 EditorialDistinct roles of dendritic and B cells in the activation of naive CD4+ T cellsChristopher D Rudulier, David R Kroeger & Peter A BretscherChristopher D RudulierDepartment of Microbiology & Immunology, University of Saskatchewan, Saskatchewan, Canada, David R KroegerDepartment of Microbiology & Immunology, University of Saskatchewan, Saskatchewan, Canada & Peter A Bretscher* Author for correspondenceDepartment of Microbiology & Immunology, University of Saskatchewan, A305–107 Wiggins Road, Saskatoon, Saskatchewan, S7N 5E5, Canada. Published Online:18 Apr 2012https://doi.org/10.2217/imt.12.17AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: autoimmunityB cellsCD4+ T cellsdendritic cellsT-cell activationReferences1 Ingulli E, Mondino A, Khoruts A, Jenkins MK. In vivo detection of dendritic cell antigen presentation to CD4(+) T cells. J. Exp. Med.185(12),2133–2141 (1997).Crossref, Medline, CAS, Google Scholar2 Garside P, Ingulli E, Merica RR, Johnson JG, Noelle RJ, Jenkins MK. Visualization of specific B and T lymphocyte interactions in the lymph node. Science281(5373),96–99 (1998).Crossref, Medline, CAS, Google Scholar3 Pereira JP, Kelly LM, Cyster JG. Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. Int. Immunol.22(6),413–419 (2010).Crossref, Medline, CAS, Google Scholar4 Haynes NM, Allen CD, Lesley R, Ansel KM, Killeen N, Cyster JG. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J. Immunol.179(8),5099–5108 (2007).Crossref, Medline, CAS, Google Scholar5 Ansel KM, Mcheyzer-Williams LJ, Ngo VN, Mcheyzer-Williams MG, Cyster JG. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J. Exp. Med.190(8),1123–1134 (1999).Crossref, Medline, CAS, Google Scholar6 Reif K, Ekland EH, Ohl L et al. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature416(6876),94–99 (2002).Crossref, Medline, Google Scholar7 Wojciechowski W, Harris DP, Sprague F et al. Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus. Immunity30(3),421–433 (2009).Crossref, Medline, CAS, Google Scholar8 Langhorne J, Cross C, Seixas E, Li C, von der Weid T. A role for B cells in the development of T cell helper function in a malaria infection in mice. Proc. Natl Acad. Sci. USA95(4),1730–1734 (1998).Crossref, Medline, CAS, Google Scholar9 Bergmann CC, Ramakrishna C, Kornacki M, Stohlman SA. Impaired T cell immunity in B cell-deficient mice following viral central nervous system infection. J. Immunol.167(3),1575–1583 (2001).Crossref, Medline, CAS, Google Scholar10 Iijima N, Linehan MM, Zamora M et al. Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus. J. Exp. Med.205(13),3041–3052 (2008).Crossref, Medline, CAS, Google Scholar11 Serreze DV, Chapman HD, Varnum DS et al. B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice. J. Exp. Med.184(5),2049–2053 (1996).Crossref, Medline, CAS, Google Scholar12 Eming R, Nagel A, Wolff-Franke S, Podstawa E, Debus D, Hertl M. Rituximab exerts a dual effect in pemphigus vulgaris. J. Invest. Dermatol.128(12),2850–2858 (2008).Crossref, Medline, CAS, Google Scholar13 Pescovitz MD, Greenbaum CJ, Krause-Steinrauf H et al. Rituximab, B-lymphocyte depletion, and preservation of beta-cell function. N. Engl. J. Med.361(22),2143–2152 (2009).Crossref, Medline, CAS, Google Scholar14 Meijer JM, Meiners PM, Vissink A et al. Effectiveness of rituximab treatment in primary Sjogren's syndrome: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum.62(4),960–968 (2010).Crossref, Medline, CAS, Google Scholar15 Abdulahad WH, Meijer JM, Kroese FG et al. B cell reconstitution and T helper cell balance after rituximab treatment of active primary Sjogren's syndrome: a double-blind, placebo-controlled study. Arthritis Rheum.63(4),1116–1123 (2011).Crossref, Medline, CAS, Google Scholar16 Chen M, Wang YH, Wang Y et al. Dendritic cell apoptosis in the maintenance of immune tolerance. Science311(5764),1160–1164 (2006).Crossref, Medline, CAS, Google Scholar17 Chen M, Huang L, Wang J. Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. Blood109(10),4360–4367 (2007).Crossref, Medline, CAS, Google Scholar18 Zwickey HL, Unternaehrer JJ, Mellman I. Presentation of self-antigens on MHC class II molecules during dendritic cell maturation. Int. Immunol.18(1),199–209 (2006).Crossref, Medline, CAS, Google Scholar19 Peters NC, Kroeger DR, Mickelwright S, Bretscher PA. CD4 T cell cooperation is required for the in vivo activation of CD4 T cells. Int. Immunol.21(11),1213–1224 (2009).Crossref, Medline, CAS, Google Scholar20 Mamula MJ. Epitope spreading: the role of self peptides and autoantigen processing by B lymphocytes. Immunol. Rev.164,231–239 (1998).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByRisk factors associated with cytomegalovirus reactivation in patients receiving immunosuppressive therapy for rheumatic diseases: a retrospective study3 December 2022 | Scientific Reports, Vol. 12, No. 1CD4+ count‐dependent concentration–effect relationship of rituximab in rheumatoid arthritis22 November 2019 | British Journal of Clinical Pharmacology, Vol. 85, No. 12Does T Cell Activation Require a Quorum of Lymphocytes?15 November 2018 | The Journal of Immunology, Vol. 201, No. 10Essential Oils as Immunomodulators: Some ExamplesOpen Chemistry, Vol. 15, No. 1Inhibitory effect of clove methanolic extract and eugenol on dendritic cell functionsJournal of Functional Foods, Vol. 27Immunosuppressive Effect of Litsea cubeba L. Essential Oil on Dendritic Cell and Contact Hypersensitivity Responses12 August 2016 | International Journal of Molecular Sciences, Vol. 17, No. 8Immunosuppressive effect of zhankuic acid C from Taiwanofungus camphoratus on dendritic cell activation and the contact hypersensitivity responseBioorganic & Medicinal Chemistry Letters, Vol. 25, No. 20 Vol. 4, No. 4 STAY CONNECTED Metrics Downloaded 220 times History Published online 18 April 2012 Published in print April 2012 Information© Future Medicine LtdKeywordsautoimmunityB cellsCD4+ T cellsdendritic cellsT-cell activationFinancial & competing interests disclosureThe authors are supported by a Discovery Grant from the Natural Sciences and Engineering Research Council of Canada (NSERC) awarded to PA Bretscher. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.005 |
| Insufficient payload (model declined to judge) | 0.006 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".