Arsenic toxicity in pathogenic Staphylococcus epidermidis and Klebsiella pneumoniae
Bibliographic record
Abstract
The sensitivity of pure cultures of Staphylococcus epidermidis and Klebsiella pneumoniae towards arsenic was studied with particular reference to biochemical changes induced by the heavy metal in these organisms. Arsenic strongly inhibited the growth and viability of both the organisms. Addition of arsenic prolonged the lag phase and this was found to be the concentration dependent phenomenon. The Minimum inhibitory concentration (MIC) determined was 200 ppm and 20 ppm in S. epidermidis and K. pneumoniae respectively that inhibited growth, synthesis of protein, DNA, RNA completely and activity of dehydrogenases of the TCA cycle. In S. epidermidis and K. pneumoniae, cell wall, membrane and cytoplasm 24.5%, 32.5%, 43% and 20%, 35%, 45% arsenic respectively got incorporated. As the activity of dehydrogenases was inhibited by arsenic, cells were incapable of oxidizing substrate. It resulted in limited supply of energy rich compounds such as ATP that affected the synthesis of macromolecules. Ultimately multiplication and growth of the organism got ceased.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".