Soft Sweeps II—Molecular Population Genetics of Adaptation from Recurrent Mutation or Migration
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No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
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- Teacher spread
- 0.245 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
In the classical model of molecular adaptation, a favored allele derives from a single mutational origin. This ignores that beneficial alleles can enter a population recurrently, either by mutation or migration, during the selective phase. In this case, descendants of several of these independent origins may contribute to the fixation. As a consequence, all ancestral haplotypes that are linked to any of these copies will be retained in the population, affecting the pattern of a selective sweep on linked neutral variation. In this study, we use analytical calculations based on coalescent theory and computer simulations to analyze molecular adaptation from recurrent mutation or migration. Under the assumption of complete linkage, we derive a robust analytical approximation for the number of ancestral haplotypes and their distribution in a sample from the population. We find that so-called "soft sweeps," where multiple ancestral haplotypes appear in a sample, are likely for biologically realistic values of mutation or migration rates.
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The record
- Venue
- Molecular Biology and Evolution
- Topic
- Evolution and Genetic Dynamics
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- —
- Funders
- Deutsche ForschungsgemeinschaftUniversity of Saskatchewan
- Keywords
- BiologyCoalescent theoryHaplotypeFixation (population genetics)GeneticsSelective sweepMutationPopulationAdaptation (eye)Evolutionary biologyAllelePopulation geneticsMolecular evolutionMutation rateAllele frequencyLinkage (software)GenePhylogenetic tree
- Has abstract in OpenAlex
- yes