Dehydrogenase Interference with Enzymatic Ethanol Assays: Forgotten but Not Gone
Bibliographic record
Abstract
We have observed a positive interference affecting the Siemens (previously Bayer) Advia 1650® ethanol assay in samples collected from 3 patients with marked hepatocellular necrosis. During a recent 2-month period, we encountered 3 cases of acetaminophen-induced hepatocellular necrosis at our institution that demonstrated this effect (Table 1⇓ ). The spurious ethanol results were in the 30–40 mmol/L range. Gas chromatography subsequently demonstrated that all 3 samples contained no detectable ethanol (<2 mmol/L). Additionally, ethanol was undetectable (<2 mmol/L) on the Dade Behring RXL MAX® platform using the Dade Behring Dimension® Flex® reagent cartridge. As it happened, we were alerted to a potential problem by …
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.006 | 0.016 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".