Estradiol‐induced enhancement in cell proliferation is mediated through estrogen receptors in the dentate gyrus of adult female rats
Why this work is in the frame
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Bibliographic record
Abstract
Abstract High‐level estradiol enhances cell proliferation in the dentate gyrus of adult female rats within 4 h of administration and then suppresses cell proliferation within 48 h via an adrenal steroid‐dependent mechanism (Ormerod et al., [2003b] J Neurobiol 55:247–260). Here, we investigate whether the estradiol‐induced enhancement in progenitor cell proliferation is mediated through estrogen receptors (ERSs) using the selective ER antagonist ICI 182,780 (ICI). Ovariectomized Sprague‐Dawley rats were given two subcutaneous injections of either vehicle + vehicle (VEH; 0.1 ml sesame oil); VEH+ICI (500 µg); estradiol benzoate (EB; 10 µg)+VEH; or EB +ICI. The cell synthesis marker, 5‐bromo‐2′‐deoxyuridine (200 mg/kg) was administered 4 h later. Animals were perfused 24 h after BrdU injection and cell proliferation was assessed following immunohistochemical processing of the tissue. Relative to VEH, EB increased cell proliferation by approximately 50%. This EB‐induced increase was partially blocked by ICI 182,780 treatment, and ICI 182,780 treatment alone enhanced cell proliferation. Our results demonstrate that estradiol enhances cell proliferation in the dentate gyrus of adult female rats by activating estrogen receptors. Drug Dev. Res. 66:142–149, 2006. © 2006 Wiley‐Liss, Inc.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it