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Short-Chain Fatty Acids in Ulcerative Colitis

2009· review· en· W2099138021 on OpenAlexaff
Young‐In Kim

Bibliographic record

VenueNutrition Reviews · 2009
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsUlcerative colitisGastroenterologyShort-chain fatty acidColitisMedicineInternal medicineProximal colonFermentationChemistryButyrateBiochemistryColorectal cancerDisease

Abstract

fetched live from OpenAlex

Short-chain fatty acids (SCFA), a by-product of anaerobic fermentation of undigested carbohydrates within the colon, are an important energy source for colonic epithelial cells. It has been proposed that ulcerative colitis, a chronic inflammatory condition of the colon, may result from a metabolic defect in SCFA oxidation in the colon and that this defect may be corrected by supraphysiologic luminal levels of SCFA in the colon. Clinical trials published to date suggest that topical SCFA provide an effective primary and/or adjunctive treatment in patients with mild to moderate distal ulcerative colitis at substantial cost savings and without significant side effects.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.970
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.039
GPT teacher head0.335
Teacher spread0.296 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations60
Published2009
Admission routes1
Has abstractyes

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