Thiol-responsive hydrogel scaffolds for rapid change in thermoresponsiveness
Bibliographic record
Abstract
A facile strategy to fabricate thiol-responsive thermoresponsive hydrogels able to rapidly change their volume in response to temperature is reported. The strategy utilizes crosslinking atom transfer radical polymerization to synthesize well-defined hydrogels of thermoresponsive oligo(ethylene oxide)-based polymethacrylates with a uniform network crosslinked with dynamic disulfides. Thiol-responsive cleavage of disulfide linkages to the corresponding pendant thiols allows for the generation of hydrophilic dangling chains in the hydrogels as well as the increase in hydrophilicity of the hydrogel network. The degraded hydrogels exhibit a rapid change of thermoresponsiveness (deswelling kinetics) with a slight sacrifice in mechanical properties. Evaluating the hydrogels from a biomedical perspective, rapid thermoresponsive hydrogels are non-cytotoxic and exhibit enhanced release of encapsulated model drugs.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".