Fluorescent Light Exposure of Rebaudioside A in Mock Beverages under International Conference on Harmonization (ICH) Guidelines
Bibliographic record
Abstract
Photostability of rebaudioside A, a sweet constituent of Stevia rebaudiana was studied under fluorescent light exposure at 25o C in mock beverages at pH 3.8 using International Conference on Harmonization (ICH) technical requirements covering the stability testing of new drug substances and products. Experimental results indicated that rebaudioside A did not undergo any major decomposition with fluorescent light exposure for 2 weeks. Identification of the degradation products furnished two minor compounds which were identified as 13-[(2-O-b-D-glucopyranosyl-3-O-b-D-glucopyranosyl]- b-D-glucopyranosyl)oxy]-17-hydroxy-ent-kaur-15-en-19-oic acid b-D-glucopyranosyl ester and 13-[(2-O-?-D-glucopyranosyl-3-O-?-D-glucopyranosyl-?-D-glucopyranosyl)oxy]-16?-hydroxy ent-kauran-19-oic acid b-D-glucopyranosyl ester on the basis of extensive spectroscopic data and chemical studies. Also, the mass balance for rebaudioside A was calculated against their control samples which were found 99.1%, suggesting any appreciable amount of undetected degradation products were formed under the conditions of the study.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".