A microfluidic device with on-chip optical waveguide interrogation of individual biological cells for medical diagnostics
Bibliographic record
Abstract
We present a microfluidic device for on-chip optical analysis and characterisation of biological cells. We employ a novel waveguiding technique for detection and analysis of the cells. This waveguiding technique is particularly well suited to this since a number of unique characteristics of the optical waveguide come together to enable detailed analysis of the very low level of scattered light. We are interested in the analysis and characterisation of sub-wavelength features such as nuclei and mitochondria within living cells. Such nanoscale probing of intracellular matter promises to offer reliable diagnostic procedures for biological cells. Of particular interest are the mitochondria, since the size and number of these can provide useful information as to the health of the cell. Mitochondria are the organelles in which energy production takes place, and as such are of vital importance. Mitochondrial abnormalities are often associated with serious diseases including cancer.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".