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Record W2101157398 · doi:10.1007/0-306-46809-3_8

Pathogenesis of Legionella pneumophila Infection

2005· book-chapter· en· W2101157398 on OpenAlexaff
Paul S. Hoffman, Rafael A. Garduño

Bibliographic record

VenueKluwer Academic Publishers eBooks · 2005
Typebook-chapter
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicLegionella and Acanthamoeba research
Canadian institutionsDalhousie University
Fundersnot available
KeywordsLegionella pneumophilaObligateIntracellularIntracellular parasiteBiologyMicrobiologyPathogenesisMacrophageLegionellaCell biologyVirologyBacteriaImmunologyGenetics

Abstract

fetched live from OpenAlex

We have attempted to present new information on the biology of the legionellae. Most new developments have focused on the events that follow host cell entry and lead to intracellular replication in macrophages or macrophage-like cell lines. However, we have also presented recent findings addressing the early events of invasion of nonphagocytic cells by L.pneumophila and the unusual role that the heat-shock protein Hsp60 may play in these early events. Readers may have grasped the wealth of potential knowledge that could be extracted from using the legionellae to model the pathogenesis and evolution of intracellular bacterial pathogens. In particular, the study of the recently discovered developmental cycle of L.pneumophila offers unique opportunities,as developmental cycles have been basically described only for obligate intracellular pathogens.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Research integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.535
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.022
GPT teacher head0.262
Teacher spread0.240 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2005
Admission routes1
Has abstractyes

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