Targeted expression of a human pituitary tumor–derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Post-publication record
- Nature
- Retraction
- Reason
- Concerns/Issues about Data;Criminal Proceedings;Duplication of/in Image;Investigation by Company/Institution;Manipulation of Images;Misconduct - Official Investigation(s) and/or Finding(s);Objections by Author(s);
- Date
- 8/3/2015 0:00
- Flagged by OpenAlex?
- Yes
Source: Retraction Watch, joined by DOI. OpenAlex records retraction as is_retracted, a boolean over a state space with at least four values, so it cannot express an expression of concern, a correction or a reinstatement — it reports them as false, which reads as “fine”.
Abstract
It is estimated that up to one in five individuals develop pituitary gland tumors. Despite the common occurrence of these tumors, the pathogenetic mechanisms underlying their development remain largely unknown. We report the identification of a novel pituitary tumor-derived, N-terminally truncated isoform of FGF receptor-4 (ptd-FGFR4). The corresponding mRNA results from alternative transcription initiation and encodes a polypeptide that lacks a signal peptide and the first two extracellular Ig-like domains. ptd-FGFR4 has a distinctive cytoplasmic residence, is constitutively phosphorylated, and is transforming in vitro and in vivo. Here we show that targeted expression of ptd-FGFR4, but not FGFR4, results in pituitary tumors that morphologically recapitulate the human disease.
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The record
- Venue
- Journal of Clinical Investigation
- Topic
- Fibroblast Growth Factor Research
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- University Health NetworkMount Sinai HospitalOntario Institute for Cancer ResearchUniversity of Toronto
- Funders
- Medical Research CouncilMedical Research Council Canada
- Keywords
- Gene isoformFibroblast growth factor receptor 4BiologyPituitary tumorsCarcinogenesisPituitary glandCancer researchReceptorFibroblast growth factor receptorIn vivoCell biologyFibroblast growth factorEndocrinologyCancerGeneGeneticsHormone
- Has abstract in OpenAlex
- yes