Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data

2014· review· en· 648 citations· W2102263282 on OpenAlex· 10.1016/s2213-2600(14)70041-4

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Full frame distilled prediction

Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

Candidate categories: Meta-epidemiology (narrow)
Consensus categories: none
Domain: Candidate signal: noneConsensus signal: none
Study design: Candidate signal: ObservationalConsensus signal: Observational
Genre: Candidate signal: ReviewConsensus signal: none
Teacher disagreement score: 0.150
Threshold uncertainty score: 1.000
Validation status: machine_predicted_unvalidated · codex-gemma-dda1882f352a

Codex and Gemma teacher scores by category

Category	Codex	Gemma
Metaresearch	0.013	0.007
Meta-epidemiology (narrow)	0.001	0.000
Meta-epidemiology (broad)	0.012	0.001
Bibliometrics	0.002	0.006
Science and technology studies	0.000	0.001
Scholarly communication	0.000	0.000
Open science	0.001	0.001
Research integrity	0.000	0.001
Insufficient payload (model declined to judge)	0.000	0.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.506

GPT teacher head0.504

Teacher spread: 0.003 · how far apart the two teachers sit on this one work
Validation status: score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

BACKGROUND: Neuraminidase inhibitors were widely used during the 2009-10 influenza A H1N1 pandemic, but evidence for their effectiveness in reducing mortality is uncertain. We did a meta-analysis of individual participant data to investigate the association between use of neuraminidase inhibitors and mortality in patients admitted to hospital with pandemic influenza A H1N1pdm09 virus infection. METHODS: We assembled data for patients (all ages) admitted to hospital worldwide with laboratory confirmed or clinically diagnosed pandemic influenza A H1N1pdm09 virus infection. We identified potential data contributors from an earlier systematic review of reported studies addressing the same research question. In our systematic review, eligible studies were done between March 1, 2009 (Mexico), or April 1, 2009 (rest of the world), until the WHO declaration of the end of the pandemic (Aug 10, 2010); however, we continued to receive data up to March 14, 2011, from ongoing studies. We did a meta-analysis of individual participant data to assess the association between neuraminidase inhibitor treatment and mortality (primary outcome), adjusting for both treatment propensity and potential confounders, using generalised linear mixed modelling. We assessed the association with time to treatment using time-dependent Cox regression shared frailty modelling. FINDINGS: We included data for 29,234 patients from 78 studies of patients admitted to hospital between Jan 2, 2009, and March 14, 2011. Compared with no treatment, neuraminidase inhibitor treatment (irrespective of timing) was associated with a reduction in mortality risk (adjusted odds ratio [OR] 0·81; 95% CI 0·70-0·93; p=0·0024). Compared with later treatment, early treatment (within 2 days of symptom onset) was associated with a reduction in mortality risk (adjusted OR 0·48; 95% CI 0·41-0·56; p<0·0001). Early treatment versus no treatment was also associated with a reduction in mortality (adjusted OR 0·50; 95% CI 0·37-0·67; p<0·0001). These associations with reduced mortality risk were less pronounced and not significant in children. There was an increase in the mortality hazard rate with each day's delay in initiation of treatment up to day 5 as compared with treatment initiated within 2 days of symptom onset (adjusted hazard ratio [HR 1·23] [95% CI 1·18-1·28]; p<0·0001 for the increasing HR with each day's delay). INTERPRETATION: We advocate early instigation of neuraminidase inhibitor treatment in adults admitted to hospital with suspected or proven influenza infection. FUNDING: F Hoffmann-La Roche.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

The record

Venue: The Lancet Respiratory Medicine
Topic: Influenza Virus Research Studies
Field: Medicine
Canadian institutions: Stollery Children's HospitalHospital for Sick ChildrenProvincial Laboratory of Public HealthUniversity of Alberta HospitalAlberta Hospital EdmontonUniversity of AlbertaSickKids FoundationUniversity of TorontoUniversity of Manitoba
Funders: National Institutes of HealthNational Institute for Health and Care ResearchRadboud Universitair Medisch CentrumEuropean Centre for Disease Prevention and ControlMedical Research CouncilRadboud Universiteit
Keywords: MedicineNeuraminidasePandemicConfoundingOdds ratioNeuraminidase inhibitorMeta-analysisOseltamivirInternal medicineConfidence intervalInfluenza A virusEmergency medicineVirusVirologyCoronavirus disease 2019 (COVID-19)Disease
Has abstract in OpenAlex: no
API: /api/v1/works/W2102263282