Bibliographic record
Abstract
Communications along the brain-gut axis involve neural pathways as well as immune and endocrine mechanisms.The two branches of the autonomic nervous system are integrated anatomically and functionally with visceral sensory pathways, and are responsible for the homeostatic regulation of gut function.The autonomic nervous system is also a major mediator of the visceral response to central influences such as psychological stress and other central factors.As presently defined, functional disorders represent a constellation of symptoms, some of which suggest the presence of altered perception while other symptoms point to disordered gastrointestinal function as the cause of the symptoms.There have been a growing number of reports demonstrating disordered autonomic function in subgroups of functional bowel patients.[1][2][3] While a number of diVerent methods were used to assess autonomic function, they generally point to decreased vagal (parasympathetic) outflow or increased sympathetic activity in conditions usually associated with slow or decreased gastrointestinal motility.Other studies found either increased cholinergic activity or decreased sympathetic activity in patients with symptoms compatible with increased motor activity.3 4 Under certain conditions, altered autonomic balance (including low vagal tone and increased sympathetic activity) may also alter visceral perception.Autonomic dysfunction could also represent the physiological pathway accounting for many of the extraintestinal symptoms seen in irritable bowel syndrome (IBS) patients, and for some of the frequent gastrointestinal complaints reported by patients with disorders such as chronic fatigue and fibromyalgia.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.002 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.003 | 0.003 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".