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Record W2104124522 · doi:10.1126/science.aab3884

Genomic evidence for the Pleistocene and recent population history of Native Americans

2015· article· en· W2104124522 on OpenAlexaff
Maanasa Raghavan, Matthias Steinrücken, Kelley Harris, Stephan Schiffels, Simon Rasmussen, Michael DeGiorgio, Anders Albrechtsen, Cristina Valdiosera, María C. Ávila‐Arcos, Anna‐Sapfo Malaspinas, Anders Eriksson, Ida Moltke, Mait Metspalu, Julian R. Homburger, Jeff Wall, Omar E. Cornejo, J. Víctor Moreno-Mayar, Thorfinn Sand Korneliussen, Tracey Pierre, Morten Rasmussen, Paula F. Campos, Peter de Barros Damgaard, Morten E. Allentoft, John Lindo, Ene Metspalu, Ricardo Varela, Josefina Mansilla Lory, Celeste Henrickson, Andaine Seguin‐Orlando, Helena Malmström, Thomas Stafford, Suyash Shringarpure, Andrés Moreno‐Estrada, Monika Karmin, Kristiina Tambets, Anders Bergström, Yali Xue, Vera Warmuth, A. D. Friend, Joy Singarayer, Paul J. Valdes, François Balloux, Ilán Leboreiro, José Luis Vera, Héctor Rangel‐Villalobos, Davide Pettener, Donata Luiselli, Loren G. Davis, Évelyne Heyer, Christoph P. E. Zollikofer, Marcia S. Ponce de León, Colin Smith, Vaughan Grimes, Kelly-Anne Pike, Michael Deal, Benjamin T. Fuller, Bernardo Arriaza, Vivien G. Standen, Maria Francisca Luz, François‐Xavier Ricaut, Niède Guidon, L. P. Osipova, Mikhail I. Voevoda, Olga L. Posukh, Oleg Balanovsky, Maria Lavryashina, Yuri Bogunov, Э. К. Хуснутдинова, Marina Gubina, Elena Balanovska, С.А. Федорова, Sergey Litvinov, B. А. Malyarchuk, М. В. Деренко, M. J. Mosher, David Archer, Jerome S. Cybulski, Barbara Petzelt, Joycelynn Mitchell, Rosita Worl, Paul J. Norman, Peter Parham, Brian M. Kemp, Toomas Kivisild, Chris Tyler-Smith, Manjinder S. Sandhu, Michael Crawford, Richard Villems, David Glenn Smith, Michael R. Waters, Ted Goebel, John R. Johnson, Ripan S. Malhi, Mattias Jakobsson, David J. Meltzer, Andrea Manica, Richard Durbin, Carlos D. Bustamante, Yun S. Song, Rasmus Nielsen, Eske Willerslev

Bibliographic record

VenueScience · 2015
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicForensic and Genetic Research
Canadian institutionsSimon Fraser UniversityWestern UniversityCoast Mountain CollegeMemorial University of Newfoundland
FundersH2020 European Research CouncilEuropean Regional Development FundAustralian Research CouncilNational Institute of General Medical SciencesH. Lundbeck A/SRussian Science FoundationWenner-Gren StiftelsernaEuropean CommissionEesti TeadusfondiMinisterio de Ciencia e InnovaciónLundbeckfondenNational Human Genome Research InstituteRussian Foundation for Basic ResearchWellcome TrustBiotechnology and Biological Sciences Research CouncilDanmarks GrundforskningsfondWashington State UniversityDirectorate for Biological SciencesNational Institutes of HealthSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungLa Trobe UniversitySocial Science Research CouncilConsejo Nacional de Ciencia y TecnologíaNational Institute of Allergy and Infectious DiseasesRussian Academy of SciencesAgence Nationale de la RechercheVillum FondenNational Science FoundationWellcomeWenner-Gren Foundation
KeywordsPleistoceneEvolutionary biologyPopulationGeographyBiologyGenealogyHistoryArchaeologyDemographySociology

Abstract

fetched live from OpenAlex

How and when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we found that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) and after no more than an 8000-year isolation period in Beringia. After their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 ka, one that is now dispersed across North and South America and the other restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative "Paleoamerican" relict populations, including the historical Mexican Pericúes and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score0.015

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0000.001
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.131
GPT teacher head0.373
Teacher spread0.242 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations571
Published2015
Admission routes1
Has abstractyes

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