Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis
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- Teacher spread
- 0.302 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
BACKGROUND: Individuals with chronic obstructive pulmonary disease (COPD) are at increased risk of cardiovascular diseases, osteoporosis, and muscle wasting. Systemic inflammation may be involved in the pathogenesis of these disorders. A study was undertaken to determine whether systemic inflammation is present in stable COPD. METHODS: A systematic review was conducted of studies which reported on the relationship between COPD, forced expiratory volume in 1 second (FEV(1)) or forced vital capacity (FVC), and levels of various systemic inflammatory markers: C-reactive protein (CRP), fibrinogen, leucocytes, tumour necrosis factor-alpha (TNF-alpha), and interleukins 6 and 8. Where possible the results were pooled together to produce a summary estimate using a random or fixed effects model. RESULTS: Fourteen original studies were identified. Overall, the standardised mean difference in the CRP level between COPD and control subjects was 0.53 units (95% confidence interval (CI) 0.34 to 0.72). The standardised mean difference in the fibrinogen level was 0.47 units (95% CI 0.29 to 0.65). Circulating leucocytes were also higher in COPD than in control subjects (standardised mean difference 0.44 units (95% CI 0.20 to 0.67)), as were serum TNF-alpha levels (standardised mean difference 0.59 units (95% CI 0.29 to 0.89)). CONCLUSIONS: Reduced lung function is associated with increased levels of systemic inflammatory markers which may have important pathophysiological and therapeutic implications for subjects with stable COPD.
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The record
- Venue
- Thorax
- Topic
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Field
- Medicine
- Canadian institutions
- University of Alberta
- Funders
- —
- Keywords
- MedicineCOPDSystemic inflammationInternal medicineFibrinogenVital capacityGastroenterologyInflammationPulmonary function testingConfidence intervalMeta-analysisPathogenesisC-reactive proteinImmunologyRisk factorLungLung functionDiffusing capacity
- Has abstract in OpenAlex
- yes