Adrenocorticotrophin- and cyclic adenosine 3′,5′-monophosphate-stimulated cortisol secretion in interrenal tissue of rainbow trout exposed in vitro to DDT compounds
Bibliographic record
Abstract
Abstract The effects of DDT compounds on the function and viability of interrenal corticosteroidogenic tissue were investigated in vitro in rainbow trout (Oncorhynchus mykiss) in a dose–response study. The o,p′-dichlorodiphenyldichloroethane (DDD) was the most potent of the tested chemicals in decreasing adrenocorticotropic hormone (ACTH)-stimulated cortisol secretion by head kidney fragments compared with controls. The dbcAMP-stimulated cortisol secretion was also impaired with doses of 50 and 100 mg/L o,p′-DDD but not 25 mg/L. Tissue viability, estimated by the release of lactate dehydrogenase (LDH), was similar to controls at 25 mg/L and was decreased significantly at 50 and 100 mg/L o,p′-DDD. These results suggest that o,p′-DDD is an adrenotoxic compound that may disrupt the 3′,5′-monophosphate (cAMP) generation step and, at higher doses, induce irreversible cytotoxic effects. The p,p′-DDT induced a significant inhibition in the secretory response to ACTH and dbcAMP only at 100 mg/L, while p,p′-DDD had no effect on the cortisol secretion. A significantly decreased viability was detected at the higher doses of p,p′-DDT and p,p′-DDD without a detectable disruption of cortisol synthesis. The steroidogenic interrenal cells may be less sensitive to the DDT compounds tested than other cell populations within the teleost head kidney.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".