Does perceived stress in pregnant immigrant women predispose their infants to allergic disease development? - a work-in-progress
Bibliographic record
Abstract
"Canada's Immigration Program" [ 1 ] reports that Canada has the highest per capita immigration rate in the world. Given the finding that pregnant immigrant women display higher prevalence of depression and anxiety disorders [ 2 ], the investigation of health outcomes in this population is warranted. The present study will examine whether prenatal perceived stress and/or physiologic maternal stress responses are associated with the development of allergies in infants, in a diverse group of immigrant women. Sixty immigrant women will be recruited early in pregnancy and followed up to 1 year postpartum. Three study visits (<24 weeks gestation, 32-36 gestation, and 1 year postpartum) and two brief phone calls (at 3- and 6-months postpartum) will be used to collect information about maternal health including perceived stress, depressive symptoms, social support, and biomarkers of stress reactivity (salivary cortisol). Information on infant birth outcomes and cord blood (for measurement of IgE) will be collected at the time of delivery. Infant atopy (assessed via skin-prick testing and clinical history) will be assessed at 1 year of age, along with information on the infant's health and stress response (salivary cortisol). To date, forty-eight women have been recruited into the study. Preliminary data illustrate a wide range of depressive symptoms, perceived stress, and social support. Ten women reported high levels of depressive symptoms (>11 on the EPDS) or high levels of perceived stress (>19 on the PSS-10), and an additional four women reported both during early- to mid-pregnanct. Thus, stress and depressive symptoms appear to be distinct phenomena in this population. Women who experienced a very large number of negative life events in the previous 6 months or reported low levels of perceived social support tended to endorse either high levels of stress or depression in early pregnancy. Participant recruitment and testing are on-going. A large portion of our (diverse) sample of immigrant women reported high levels of perceived stress and/or depressive symptoms during early- to mid-pregnancy. Whether these adverse perinatal mental states (and their associated dysregulated stress responses) contribute to the development of allergic disease in infants is under active, prospective investigation. A better understanding of the effects of perinatal factors on susceptibility to allergic disease in the infant can lead to development of interventions when plasticity in physiologic development is still relatively abundant [ 3 ].
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".