Comments on Classical and Atypical Scrapie in Domestic Sheep and Goats
Bibliographic record
Abstract
Scrapie is a neurodegenerative disease in domestic sheep and goats. Scrapie has a long incubation period that can vary from two to five years. The etiology is an extremely stable isoform (PrP8c) of the normal cellular prion protein (PrPc). The accumulation of this protein in the brain is thought to result in the spongiform encephalopathy that characterizes the disease. Scrapie has been reported in the United Kingdom, Ireland, most European countries, Canada, the United States, India and Japan, but not in Australia and New Zealand. Clinical signs are mostly neurological and diagnosis is usually made with immunohistochemical staining of the brainstem and retropharyngeal lymph nodes. Genetics plays a significant role in the susceptibility and incubation period of the disease and is used in control strategies. The primary method of prevention is maintenance of a closed ewe flock, purchase of sheep from uninfected farms enrolled in an approved flock certification program, or purchase of genetically resistant stock. Following diagnosis of scrapie in a flock, depopulation of genetically susceptible sheep is the only effective control measure at this time. If a sheep or goat flock is diagnosed with atypical scrapie the herd is depopulated.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".