Altering the properties of the blood-brain barrier: disruption and permeabilization
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
By way of its intrinsic structural and physiological properties, the blood-brain barrier (BBB) represents a formidable obstacle to the delivery of drug to the central nervous system. The treatments of many diseases affecting the central nervous system is thereby complicated by the aspect of delivery, that is, insuring that the therapeutic molecule will reach the target cell in sufficient concentration, and in a suitable timing for the treatment to be effective. Although many different etiologic conditions will be affected by this delivery impediment, in no other condition has it been as extensively documented as in malignant brain tumors. Brain tumor is the prototypical situation through which one can best exemplify the problematic of delivery across the blood-brain barrier. We will therefore frequently refer to this particular problematic, acknowledging the fact that a lot of research endeavour in this field was undertaken as alternate strategies in the treatment of brain tumors. However, by no means will we imply that these strategies should be restricted to the treatment of cerebral malignancies.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it