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Record W2106013076 · doi:10.1126/science.287.5461.2204

Comparative Genomics of the Eukaryotes

2000· article· en· W2106013076 on OpenAlexaff
Gerald M. Rubin, Mark Yandell, Jennifer R. Wortman, George L. Gabor, Miklós, Catherine R. Nelson, Iswar K. Hariharan, Mark Fortini, Peter W. Li, Rolf Apweiler, Wolfgang Fleischmann, J. Michael Cherry, Steven Henikoff, Marian Skupski, Sima Misra, Michael Ashburner, Ewan Birney, Mark S. Boguski, Thomas Brody, Peter Brokstein, S Celniker, Stephen A. Chervitz, David Coates, Anibal Cravchik, Andrei Gabrielian, Richard F. Galle, William M Gelbart, Reed George, Lawrence S.B. Goldstein, Fangcheng Gong, Ping Guan, Nomi L. Harris, Bruce A. Hay, Roger A. Hoskins, Jiayin Li, Zhenya Li, Richard O. Hynes, Steven J.M. Jones, Peter Kuehl, Bruno Lemaître, J. Troy Littleton, Deborah K. Morrison, Chris Mungall, Patrick H. O’Farrell, Oxana K. Pickeral, Chris Shue, Leslie B. Vosshall, Jiong Zhang, Qi Zhao, Xiangqun Zheng-Bradley, Fei Zhong, Wenyan Zhong, Richard A. Gibbs, J. Craig Venter, Mark D. Adams, Suzanna Lewis

Bibliographic record

VenueScience · 2000
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenomics and Chromatin Dynamics
Canadian institutionsCanada's Michael Smith Genome Sciences CentreGenome British Columbia
FundersNational Institute of General Medical SciencesNational Institute of Neurological Disorders and StrokeNational Human Genome Research Institute
KeywordsDrosophila melanogasterCaenorhabditis elegansBiologyGenomeComparative genomicsModel organismENCODEGeneGeneticsContext (archaeology)Saccharomyces cerevisiaeComputational biologyMelanogasterGenomicsDrosophila (subgenus)Yeast

Abstract

fetched live from OpenAlex

A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.002
Threshold uncertainty score0.006

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0010.001
Open science0.0000.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.238
Teacher spread0.230 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1,701
Published2000
Admission routes1
Has abstractyes

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