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Record W2106909144 · doi:10.1101/sqb.2009.74.003

The Oligogenic View of Adaptation

2009· review· en· W2106909144 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueCold Spring Harbor Symposia on Quantitative Biology · 2009
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetic Mapping and Diversity in Plants and Animals
Canadian institutionsMcGill University
Fundersnot available
KeywordsAdaptation (eye)Computational biologyComputer scienceBiologyNeuroscience

Abstract

fetched live from OpenAlex

The traditional view is that evolution proceeds very slowly, over immense periods of time, driven by weak selection acting on innumerable genes of small effect. Recent studies of rapid evolution, in the laboratory and in the field, have given a radically different picture. Although beneficial mutations tend to be small in effect when they first appear, those that survive to spread and become fixed are usually among the minority with large effect. Hence, although hundreds of loci of small effect may contribute to variation in character state, adaptation is predominantly caused by alleles of large effect. This leads to the hope that the particular mutations responsible for adaptation to altered conditions of life can be identified and characterized. This has been achieved in some cases and may soon become routine. Furthermore, it raises the possibility that adaptive change can be predicted from a knowledge of genetics and ecology. Experimental evolution suggests that any given selection line that is adapting to changed conditions will follow one of a few themes (broadly speaking, loci), each of which may have many variations (mutations within the locus producing similar phenotypes). Hence, evolutionary change can be predicted only within limits, even in principle. Nevertheless, recent attempts to predict how very simple genomes change have been surprisingly successful, and we may be close to a new predictive understanding of the genetic basis of adaptation.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.997
Threshold uncertainty score0.915

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.052
GPT teacher head0.320
Teacher spread0.267 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it