Host Defense against Common Early Life-Threatening Infections
Bibliographic record
Abstract
Neonates suffer more severely and die more often than adults from a wide range of infections [1]. Although quantitative differences between neonatal and adult immune capacity are known, the molecular basis for the transition of immunologic function from fetal to postnatal life has remained a mystery. However, over the past decade, there has been an explosion of knowledge on immunity of the newborn and its importance to early host response to infection. Recent advances in developmental immunology now allow us to better understand the mechanisms underlying the susceptibility of neonates to many bacterial and viral infections [2, 3]. In addition, neonatal intestinal microbial ecology is now appreciated to play a role in host defenses and in the pathogenesis of neonatal necrotizing enterocolitis (NEC) [4]. In this special issue, we have collected reviews and papers to provide insight in immunologic adaptation of the neonate to its new environment and the consequences of this transition to newborn host defense mechanisms to bacterial and viral infection.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".