Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
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Abstract
The National Institutes of Health Mammalian Gene Collection (MGC) Program is a multiinstitutional effort to identify and sequence a cDNA clone containing a complete ORF for each human and mouse gene. ESTs were generated from libraries enriched for full-length cDNAs and analyzed to identify candidate full-ORF clones, which then were sequenced to high accuracy. The MGC has currently sequenced and verified the full ORF for a nonredundant set of >9,000 human and >6,000 mouse genes. Candidate full-ORF clones for an additional 7,800 human and 3,500 mouse genes also have been identified. All MGC sequences and clones are available without restriction through public databases and clone distribution networks (see http:mgc.nci.nih.gov).
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The record
- Venue
- Proceedings of the National Academy of Sciences
- Topic
- Molecular Biology Techniques and Applications
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- —
- Funders
- National Center for Research ResourcesNational Institute of Child Health and Human DevelopmentNational Institute of Allergy and Infectious DiseasesNational Institute on Deafness and Other Communication DisordersNational Human Genome Research InstituteNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute of Mental HealthNational Heart, Lung, and Blood InstituteNational Cancer InstituteNational Institutes of HealthCanada's Michael Smith Genome Sciences CentreNational Institute of General Medical SciencesU.S. National Library of MedicineMassachusetts Institute of Technology
- Keywords
- GeneBiologyclone (Java method)Complementary DNAGeneticsExpressed sequence tagcDNA libraryOpen reading frameGenomic libraryComputational biologyMolecular biologyPeptide sequence
- Has abstract in OpenAlex
- yes