Perioperative or Adjuvant Therapy for Resectable Colorectal Hepatic Metastases
Bibliographic record
Abstract
No one will deny that the only potential curative treatment for patients with hepatic metastases from colorectal cancer is surgical resection. Although nomore than 10 % to 15 % of patients with colo-rectal cancer metastases are considered resectable for cure, the 5-year survival in this population approaches 35%.Nevertheless, relapse can occur in 75 % of patients, generally occurring within the first 2 years after surgery; 50%of relapses are in the liver.With these data, it would seem prudent to consider in these patients administering systemic agents to reduce the risk of recurrence and to potentially improve overall survival, based on the model of eradicating micrometastases with chemotherapy in early-stage primary colorectal cancer. A di-lemma that we face today is whether these agents be given before hepatic resection or after surgery. It is therefore important to clarify definitions. For example,neoadjuvant therapy is theadministrationof preoperative systemic therapy for resectable hepatic metastases. In
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.005 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.006 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".