Mechanical properties of mammalian cells in suspension measured by electro-deformation
Why this work is in the frame
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Bibliographic record
Abstract
We describe a planar, micro-fabricated device for generating fringing non-uniform electric fields. We used it to measure the mechanical properties of individual mammalian cells in suspension by deforming them in time-varying, non-uniform electric fields. Electrical stresses generated by the planar microelectrodes were used to trap and stretch cells, while cell deformation was observed using optical microscopy. Two distinct cell types were compared after fitting strain data with a three-parameter 'standard linear solid' model of visco-elasticity, and with a two-parameter power-law method. Chinese hamster ovary (CHO) cells were approximately twice as stiff as U937 human promonocytes, and CHO cells displayed an elastic behaviour with recovery of initial shape, while U937 strain data bore witness to plastic deformation. Our results demonstrate that electrical stresses generated by micro-fabricated electrodes permit mechanical characterization of distinct mammalian cell types.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it