F3‐01‐03: Goal‐oriented cognitive rehabilitation of memory in early‐stage Alzheimer's disease: Single‐blind randomized controlled trial of clinical efficacy
Bibliographic record
Abstract
This single-blind randomized controlled trial aimed to provide evidence regarding the clinical efficacy of cognitive rehabilitation (CR) in early-stage Alzheimer's disease (AD). Participants were 69 individuals (41 female, 28 male; mean age 77.78, sd 6.32, range 56-89) with a diagnosis of AD or mixed AD and vascular dementia and an MMSE score of 18 or above, and receiving a stable dose of acetylcholinesterase-inhibiting medication. Forty-four family carers also contributed. Participants were randomized to either CR, relaxation therapy (RT) or no treatment (NT). The CR group received 8 weekly individual home-based sessions of CR incorporating work on personally-relevant goals supported by components addressing practical aids and strategies, techniques for learning new information, practice in maintaining attention and concentration, and techniques for stress management. The primary outcomes were goal performance and satisfaction, assessed using the Canadian Occupational Performance Measure. Questionnaires assessing mood, quality of life and carer strain, and a brief neuropsychological test battery, were also administered. A subset of participants underwent functional magnetic resonance imaging (fMRI). CR produced significant improvement in ratings of goal performance and satisfaction, while scores in the other two groups did not change. At six-month follow-up, the CR group rated their memory performance more positively than did RT and NT. Behavioral changes in the CR group were supported by fMRI data for a sub-set of participants. The findings support the clinical efficacy of CR in early-stage AD. The study was funded by the UK Alzheimer's Society.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.003 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.006 | 0.002 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.004 | 0.003 |
| Insufficient payload (model declined to judge) | 0.014 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".