No change in spontaneous mutation frequency or specificity in dietary restricted mice
Bibliographic record
Abstract
It is well known that dietary restricted rodents live longer and are generally healthier than their ad libitum fed counterparts, with fewer tumors. Additionally, while dietary restriction appears to reduce the frequency of chemically induced mutation in laboratory animals, relatively little is known regarding the effect of dietary restriction on spontaneous mutational events. Although spontaneous mutation rates are generally low compared with chemically induced events, spontaneous mutations accumulate in most tissues over the lifetime of the animal and are therefore expected to contribute significantly to spontaneous neoplasia. It is generally presumed that dietary restriction results in less oxidative damage and a lowering of the mutation frequency. Here we report the results of dietary restriction on mutation frequency and specificity in lacI transgenic mice aged 6 and 12 months. Unexpectedly, no changes were observed in either the frequency or specificity of mutation in dietary restricted mice, compared with ad libitum controls. We therefore conclude that dietary restriction appears to have no appreciable effect on spontaneous mutation, at least in chromosomal DNA.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".