← Back to cohort
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
Dan E. Arking, Sara L. Pulit, Lia Crotti, Pim van der Harst, Patricia B. Munroe, Tamara T. Koopmann, Nona Sotoodehnia, Elizabeth J. Rossin, Michael P. Morley, Xinchen Wang, Andrew D. Johnson, Alicia Lundby, Daníel F. Guðbjartsson, Peter A. Noseworthy, Mark Eijgelsheim, Yuki Bradford, Kirill V. Tarasov, Marcus Dörr, Martina Müller‐Nurasyid, Annukka M. Lahtinen, Ilja M. Nolte, Albert V. Smith, Aaron Isaacs, Stephen Newhouse, Daniel S. Evans, Wendy S. Post, Daryl Waggott, Leo‐Pekka Lyytikäinen, Andrew A. Hicks, Lewin Eisele, David Ellinghaus, Caroline Hayward, Pau Navarro, Sheila Ulivi, Toshiko Tanaka, David J. Tester, Stéphanie Chatel, Stefan Gustafsson, Meena Kumari, Richard Morris, Åsa Torinsson Naluai, Sandosh Padmanabhan, Alexander Kluttig, Bernhard Strohmer, Andrie G. Panayiotou, María Torres, Michael Knoflach, Jaroslav A. Hubáček, Kamil Slowikowski, Soumya Raychaudhuri, Runjun D. Kumar, Tamara B. Harris, Lenore J. Launer, Alan R. Shuldiner, Álvaro Alonso, Joel S. Bader, Georg Ehret, Hailiang Huang, W.H. Linda Kao, James B. Strait, Peter W. Macfarlane, Mark J. Caulfield, Nilesh J. Samani, Florian Kronenberg, Johann Willeit, J. Gustav Smith, Karin Halina Greiser, Henriette E. Meyer zu Schwabedissen, Karl Werdan, Massimo Carella, Leopoldo Zelante, Susan R. Heckbert, Bruce M. Psaty, Jerome I. Rotter, Ivana Kolčić, Ozren Polašek, Alan F. Wright, Maura Griffin, Mark J. Daly, Davíð O. Arnar, Hilma Hólm, Unnur Þorsteinsdóttir, Joshua C. Denny, Dan M. Roden, Rebecca L. Zuvich, Valur Emilsson, Andrew Plump, Martin G. Larson, Christopher J. O’Donnell, Xiaoyan Yin, Marco Bobbo, Pio D’Adamo, Gianfranco Sinagra, Ãngel Carracedo, Steven R. Cummings, Michael A. Nalls, Antti Jula, Kimmo Kontula, Annukka Marjamaa, Lasse Oikarinen, Markus Perola, Kimmo Porthan, Raimund Erbel, Per Hoffmann, Karl-Heinz Jöckel, Hagen Kälsch, Markus M. Nöthen, Marcel den Hoed, Ruth J. F. Loos, Dag S. Thelle, Christian Gieger, Thomas Meitinger, Siegfried Perz, Annette Peters, Hanna Prucha, Moritz F. Sinner, Mélanie Waldenberger, Rudolf A. de Boer, Lude Franke, Pieter A. van der Vleuten, Britt Maria Beckmann, Eimo Martens, Abdennasser Bardai, Nynke Hofman, Arthur A.M. Wilde, Elijah R. Behr, Chrysoula Dalageorgou, John R. Giudicessi, Argelia Medeiros‐Domingo, Julien Barc, Florence Kyndt, Vincent Probst, Alice Ghidoni, Roberto Insolia, Robert M. Hamilton, Stephen W. Scherer, Jeffrey Brandimarto, Kenneth B. Margulies, Christine E Moravec, Fabiola Del Greco M, Christian Fuchsberger, Jeffrey R. O’Connell, Wai Lee, Graham Watt, Harry Campbell, Sarah H. Wild, Nour Eddine El Mokhtari, Norbert Frey, Folkert W. Asselbergs, Irene Mateo Leach, Gerjan Navis, Maarten P. van den Berg, Dirk J. van Veldhuisen, Manolis Kellis, Bouwe P. Krijthe, Oscar H. Franco, Albert Hofman, Jan A. Kors, André G. Uitterlinden, Jacqueline C.M. Witteman, Lyudmyla Kedenko, Claudia Lamina, Ben A. Oostra, Gonçalo R. Abecasis, Edward G. Lakatta, Antonella Mulas, Marco Orrù, David Schlessinger, Manuela Uda, Marcello Ricardo Paulista Markus, Uwe Völker, Harold Snieder, Timothy D. Spector, Johan Ärnlöv, Lars Lind, Johan Sundström, Ann-Christine Syvänen, Mika Kivimäki, Mika Kähönen, Nina Mononen, Olli T. Raitakari, Jorma Viikari, Věra Adámková, Stefan Kiechl, Marı́a Brión, Andrew Nicolaides, Bernhard Paulweber, Johannes Haerting, Anna F. Dominiczak, Fredrik Nyberg, Peter H. Whincup, Aroon D. Hingorani, Jean‐Jacques Schott, Connie R. Bezzina, Erik Ingelsson, Luigi Ferrucci, Paolo Gasparini, James F. Wilson, Igor Rudan, André Franke, Peter P. Pramstaller, Terho Lehtimäki, Andrew D. Paterson, Afshin Parsa, Ching‐Ti Liu, Cornelia M. van Duijn, David S. Siscovick, Vilmundur Guðnason, Yalda Jamshidi, Veikko Salomaa, Stephan B. Felix, Serena Sanna, Marylyn D. Ritchie, Bruno H. Stricker, Kāri Stefánsson, Laurie A. Boyer, Thomas P. Cappola, Jesper V. Olsen, Kasper Lage, Peter J. Schwartz, Stefan Kääb, Aravinda Chakravarti, Michael J. Ackerman, Arne Pfeufer, Paul I. W. de Bakker, Christopher Newton‐Cheh
Bibliographic record
VenueNature Genetics · 2014
Typereview
Languageen
FieldMedicine
TopicCardiac electrophysiology and arrhythmias
Canadian institutionsSickKids FoundationHospital for Sick ChildrenOntario Institute for Cancer Research
FundersNational Center for Advancing Translational SciencesBritish Heart FoundationNational Institute of Diabetes and Digestive and Kidney DiseasesNational Heart, Lung, and Blood InstituteNational Human Genome Research InstituteEconomic and Social Research CouncilNational Institute of General Medical SciencesMedical Research CouncilNational Institute for Health and Care Research
KeywordsBiologyRepolarizationQT intervalAssociation (psychology)Signal transductionGenetic associationCalciumInternal medicineGeneticsSingle-nucleotide polymorphismNeuroscienceGenotypeMedicineGeneElectrophysiology
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.002
Threshold uncertainty score0.007
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.018
GPT teacher head0.308
Teacher spread0.290 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations335
Published2014
Admission routes1
Has abstractno