MétaCan
Menu
Back to cohort
Record W2110564803 · doi:10.1017/s0021859607007629

Modelling bovine spongiform encephalopathy

2008· article· en· W2110564803 on OpenAlexaff
J. H. M. Thornley, J. France

Bibliographic record

VenueThe Journal of Agricultural Science · 2008
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPrion Diseases and Protein Misfolding
Canadian institutionsUniversity of Guelph
Fundersnot available
KeywordsBovine spongiform encephalopathyInfectivityOutbreakEpidemic modelScalingBiologyDiseaseComputer scienceMathematicsVirologyPrion proteinMedicineEnvironmental health

Abstract

fetched live from OpenAlex

SUMMARY A deterministic model for the spread of an important animal disease, bovine spongiform encephalopathy (BSE), is described. It is a sparse three-pool model, the pools corresponding to susceptible, infected and sick animals. Simulations illustrate the biological meaning of the parameters, and pinpoint how parameters affect epidemic characteristics: infectivity impacts on the leading edge of the epidemic and its intensity. The times when infection is introduced and when control is exercised determine the length and possibly the intensity of the epidemic. Finally, the (single) incubation rate influences the trailing edge of the epidemic. It is applied to data describing the recent UK BSE outbreak, with reasonable success. Apart from a scaling factor, only these four quantities were adjusted to achieve this. The contributions from greater modelling complexity are discussed. It is concluded that the simple model is well suited for grasping the essentials, whereas further detail is needed for a more mechanistic representation, in particular concerning incubation delays in developing infectiousness and clinical sickness.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.167
Threshold uncertainty score0.248

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.224
Teacher spread0.210 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations6
Published2008
Admission routes1
Has abstractyes

Explore more

Same venueThe Journal of Agricultural ScienceSame topicPrion Diseases and Protein MisfoldingFrench-language works237,207