Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy
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No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Abstract
BACKGROUND: The natural history, management, and outcome of takotsubo (stress) cardiomyopathy are incompletely understood. METHODS: The International Takotsubo Registry, a consortium of 26 centers in Europe and the United States, was established to investigate clinical features, prognostic predictors, and outcome of takotsubo cardiomyopathy. Patients were compared with age- and sex-matched patients who had an acute coronary syndrome. RESULTS: Of 1750 patients with takotsubo cardiomyopathy, 89.8% were women (mean age, 66.8 years). Emotional triggers were not as common as physical triggers (27.7% vs. 36.0%), and 28.5% of patients had no evident trigger. Among patients with takotsubo cardiomyopathy, as compared with an acute coronary syndrome, rates of neurologic or psychiatric disorders were higher (55.8% vs. 25.7%) and the mean left ventricular ejection fraction was markedly lower (40.7±11.2% vs. 51.5±12.3%) (P<0.001 for both comparisons). Rates of severe in-hospital complications including shock and death were similar in the two groups (P=0.93). Physical triggers, acute neurologic or psychiatric diseases, high troponin levels, and a low ejection fraction on admission were independent predictors for in-hospital complications. During long-term follow-up, the rate of major adverse cardiac and cerebrovascular events was 9.9% per patient-year, and the rate of death was 5.6% per patient-year. CONCLUSIONS: Patients with takotsubo cardiomyopathy had a higher prevalence of neurologic or psychiatric disorders than did those with an acute coronary syndrome. This condition represents an acute heart failure syndrome with substantial morbidity and mortality. (Funded by the Mach-Gaensslen Foundation and others; ClinicalTrials.gov number, NCT01947621.).
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The record
- Venue
- New England Journal of Medicine
- Topic
- Takotsubo Cardiomyopathy and Associated Phenomena
- Field
- Medicine
- Canadian institutions
- —
- Funders
- Abbott VascularSt. Jude MedicalServierUniversität ZürichHerzstiftung OltenMach-Gaensslen Foundation of CanadaBiosense WebsterSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungFoundation for Cardiovascular ResearchSchweizerische HerzstiftungAstraZenecaEli Lilly and CompanyEdwards LifesciencesPfizerBoston Scientific CorporationNational Science Foundation
- Keywords
- MedicineCardiomyopathyEjection fractionAcute coronary syndromeInternal medicineCardiologyTroponinHeart failureChest painMyocardial infarction
- Has abstract in OpenAlex
- yes