Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
Class I and class II Arfs localize to the Golgi complex where they activate lipid-modifying enzymes and also promote the recruitment of several coat proteins implicated in the sorting of cargo into budding transport vesicles. Three families of large GEFs spatially and temporally regulate Arf activation in this organelle. GBF1, a BFA-resistant GEF with specificity for Class II Arfs in vitro, localizes to cis-compartments of the Golgi and appears to regulate assembly of the COPI coat. In contrast, BIG1 and BIG2 are BFA-sensitive GEFs that concentrate on trans-compartments where they control the recruitment of clathrin adaptor proteins. BRAG1, a representative of the third family, is confined to early Golgi compartments, but unlike GBF1 displays broader Arf substrate specificity. These large GEFs are likely multidomain proteins with complex interactions responsible for regulating activity, membrane association and possibly the selection of downstream effectors. Ongoing efforts in several laboratories focus on the identification of partners for these GEFs.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it