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Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database

2012· review· en· 543 citations· W2111957326 on OpenAlex· 10.1371/journal.pgen.1002548

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Full frame distilled prediction

Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

Candidate categories
Meta-epidemiology (narrow)
Consensus categories
none
Domain
Candidate signal: noneConsensus signal: none
Study design
Candidate signal: Systematic reviewConsensus signal: none
Genre
Candidate signal: ReviewConsensus signal: Review
Teacher disagreement score
0.866
Threshold uncertainty score
1.000
Validation status
machine_predicted_unvalidated · codex-gemma-dda1882f352a

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0040.001
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.001
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.534
GPT teacher head0.468
Teacher spread
0.066 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

OpenAlex records an abstract for this work, but it could not be fetched just now.

The record

Venue
PLoS Genetics
Topic
Parkinson's Disease Mechanisms and Treatments
Field
Medicine
Canadian institutions
University of British Columbia
Funders
National Center for Research ResourcesNational Institute of Environmental Health SciencesNational Cancer InstituteNational Institute on AgingFoundation for Biomedical Research and InnovationBundesministerium für Bildung und ForschungEisaiParkinson's UKEMD SeronoHermann und Lilly Schilling-Stiftung für Medizinische ForschungU.S. Department of DefenseEli Lilly and CompanyEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Alliance for Research on Schizophrenia and DepressionH. Lundbeck A/SFidelity BiosciencesNational Institute of Neurological Disorders and StrokePrize4LifeCure Alzheimer's FundU.S. Department of Health and Human ServicesDeutscher Akademischer AustauschdienstMayo Foundation for Medical Education and ResearchNational Institutes of HealthVolkswagen FoundationMichael J. Fox Foundation for Parkinson's ResearchNorthShore University HealthSystemMayo ClinicAlnylam Pharmaceuticals
Keywords
Genome-wide association studyMeta-analysisBiologyGenetic associationImputation (statistics)Single-nucleotide polymorphismGenetics1000 Genomes ProjectBioinformaticsComputational biologyGenotypeMedicineGeneMissing dataComputer scienceInternal medicine
Has abstract in OpenAlex
yes