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Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

2012· article· en· 750 citations· W2112538318 on OpenAlex· 10.1038/nn.3230

Why is this work in the frame?

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

Canadian affiliationAn author listed a Canadian institution. This is the only route the usual frame has.

Machine scores (provisional)

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Opus teacher head0.026
GPT teacher head0.334
Teacher spread
0.308 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Abstract

No abstract. This is not a gap in this database — OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

The record

Venue
Nature Neuroscience
Topic
Amyotrophic Lateral Sclerosis Research
Field
Medicine
Canadian institutions
University of Manitoba
Funders
National Institute of Neurological Disorders and StrokeNational Human Genome Research InstituteNational Institute of General Medical SciencesWellcome Trust
Keywords
BiologyRNA splicingIntronRNA-binding proteinAmyotrophic lateral sclerosisCell biologyGeneRNA recognition motifAlternative splicingMessenger RNARNAMolecular biologyGeneticsPathologyMedicine
Has abstract in OpenAlex
no