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Record W2114408531 · doi:10.1136/adc.2009.181172

The global burden of Rh disease

2010· article· en· W2114408531 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
aboutThe title or abstract carries a Canadian signal from the geographic lexicon.

Bibliographic record

VenueArchives of Disease in Childhood Fetal & Neonatal · 2010
Typearticle
Languageen
FieldMedicine
TopicBlood groups and transfusion
Canadian institutionsHospital for Sick ChildrenSickKids Foundation
Fundersnot available
KeywordsHaemolytic diseaseMedicineJaundiceDiseasePregnancyPediatricsRh blood group systemBrain diseaseObstetricsAntibodyInternal medicineFetusImmunology

Abstract

fetched live from OpenAlex

Rh negative women who deliver an Rh positive baby are at risk of developing anti-Rh antibodies.1 Rh positive babies born of these mothers will develop Rh haemolytic disease. This is a severe condition responsible for death in utero or in the neonatal period or severe jaundice with ensuing brain damage. The natural history of the disease has not been described in recent literature. Walker,1 in 1971, reviewed a series of cases from his community. It was found that 14% of affected pregnancies resulted in stillbirths. Of the survivors, 30% had severe disease almost certainly fatal without treatment, while an additional 30% had moderate disease which would manifest as severe hyperbilirubinaemia that untreated may result in brain damage and/or death. Forty per cent of cases would require no treatment. Therefore, it can be estimated that approximately 50% of children with untreated haemolytic disease of the newborn (HDN) will die of the disease or develop brain damage. Similar observations were made in Manitoba, Canada.2 Over 30 years ago it was established that Rh isoimmunisation could be prevented by passive immunisation with anti-Rh (anti-D) γ globulin.3 4 Thereafter, prevention of Rh disease was instituted using postpartum injections of anti-Rh (anti-D) γ globulin; this has been proven to be highly effective.5 In most developed, high income countries, all Rh negative postpartum women whose babies are Rh positive …

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.337
Threshold uncertainty score0.527

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.231
Teacher spread0.228 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it