Does dominant pedunculopontine nucleus exist?
Bibliographic record
Abstract
Sir, We read with great interest the paper by Fling et al. (2013) recently published in Brain . In this imaging study, patients with Parkinson’s disease with freezing of gait (FOG), without FOG, and age-matched controls were studied with diffusion tensor imaging to identify group and inter-hemispheric differences of tract quality and quantity in the pedunculopontine nucleus (PPN) network. Interestingly, patients with Parkinson’s disease with FOG had significantly less right PPN tract volume in terms of absolute values and ratio with the left side (i.e. greater laterality index) compared to patients without FOG. Furthermore, solely in the Parkinson’s disease with FOG group, linear regression analysis significantly correlated greater lateralization of PPN tract volume with poorer performance in action inhibition tasks. The authors concluded that right hemispheric circuitry might be uniquely involved in the pathophysiology of FOG (Fling et al. , 2013). In keeping with these findings, clinical evidence from the DATATOP cohort supports the notion …
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".