Mannose-Binding Lectin Deficiency and Its Impact on Pulmonary Morbidity in Children
Bibliographic record
Abstract
A mannose-binding lectin (MBL) deficiency, due to MBL2 gene polymorphisms, is suggested to increase susceptibility to respiratory tract infections, particularly in young children. This study aimed to determine whether a MBL deficiency might be associated with pulmonary morbidity in children with recurrent pulmonary infections of unknown pathogenesis. We performed a retrospective, cross-sectional study on children referred to a tertiary pediatric pulmonary center between 2006 and 2011. We included children with a conclusive MBL2 genotype that exhibited recurrent pulmonary infections without any obvious explanatory findings. Pulmonary morbidity was estimated by lung function, body mass index, antibiotic prescriptions, and the odds ratio of radiological structural lung changes, assessed with chest X-rays or high-resolution computed tomography. One hundred thirteen children were included. No significant differences in lung function (z-scores), body mass index, or the number of annual courses of antibiotics per year could be demonstrated between high- and low-expression MBL2 genotypes. The odds ratio of structural lung changes was not related to the MBL2 genotypes. Pulmonary morbidity was not associated with low-expression MBL2 genotypes in a highly selected, although heterogeneous, group of children with recurrent pulmonary infections of unknown pathogenesis. Thus, most likely, a MBL genotyping cannot be used as a single, explanatory, causative factor for detecting differences in pulmonary morbidity in children.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".