A CMOS Contact Imager for Cell Detection in Bio-Sensing Applications
Why this work is in the frame
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Bibliographic record
Abstract
Many experimental procedures in cell biology rely on the use of biochemical light-emitting reporters to enhance structures or processes of interest in a cell sample. The ability to integrate these widely-used protocols on the surface of a CMOS biosensor array, combined with the capacity to perform cell actuation/stimulation, would provide researchers with a valuable tool to conduct high-throughput, high-density, accurate analyses. To this end, a low noise, high-sensitivity CMOS contact imager is presented for the detection of cell cultures coupled directly to the sensor surface. Design considerations are discussed for the application of neural activity recording of neuronal networks cultured <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in vitro</i> from dissociated neuron cells. A 128 × 128 CMOS imager implemented in 0.18-μm CMOS technology is presented featuring the implementation of the active reset technique with the use of the active column sensor pixel architecture.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it