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Record W2117706634 · doi:10.1371/journal.pmed.1001383

Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

2013· review· en· W2117706634 on OpenAlexafffund
Karani S. Vimaleswaran, Diane J. Berry, Lu Chen, Emmi Tikkanen, Stefan Pilz, Linda T. Hiraki, Jason D. Cooper, Zari Dastani, Rui Li, Denise K. Houston, Andrew R. Wood, Karl Michaëlsson, Liesbeth Vandenput, Lina Zgaga, Laura M. Yerges-Armstrong, Mark I. McCarthy, Josée Dupuis, Marika Kaakinen, Marcus E. Kleber, Anthony James, Nigel Arden, Olli Raitakari, Jorma Viikari, Kurt K. Lohman, Luigi Ferrucci, Håkan Melhus, Erik Ingelsson, Liisa Byberg, Lars Lind, Mattias Lorentzon, Veikko Salomaa, Harry Campbell, Malcolm G. Dunlop, Braxton D. Mitchell, Karl-Heinz Herzig, Anneli Pouta, Anna-Liisa Hartikainen, Elizabeth A. Streeten, Evropi Τheodoratou, Antti Jula, Nicholas J. Wareham, Claes Ohlsson, Timothy M. Frayling, Stephen B. Kritchevsky, Timothy D. Spector, J. Brent Richards, Terho Lehtimäki, Willem H. Ouwehand, Peter Kraft, Cyrus Cooper, Winfried März, Chris Power, Ruth J. F. Loos, Thomas J. Wang, Marjo‐Riitta Järvelin, John C. Whittaker, Aroon D. Hingorani, Elina Hyppönen

Bibliographic record

VenuePLoS Medicine · 2013
Typereview
Languageen
FieldMedicine
TopicVitamin D Research Studies
Canadian institutionsMcGill UniversityJewish General Hospital
FundersNational Institute on AgingCanadian Institutes of Health ResearchServierCancer Research UKNovo Nordisk FondenNational Institute on Alcohol Abuse and AlcoholismBritish Heart FoundationUniversity College LondonNational Institute for Health and Care ResearchMedical Research CouncilVersus ArthritisLondon School of Hygiene and Tropical MedicineEli Lilly and CompanyGreat Ormond Street Hospital for ChildrenWellcome TrustGlaxoSmithKlineAmgen
KeywordsMendelian randomizationBody mass indexMedicineObesitySingle-nucleotide polymorphismVitamin D and neurologyInternal medicineAnthropometryAlleleClinical nutritionGeneticsBiologyGenotypeGeneGenetic variants

Abstract

fetched live from OpenAlex

OpenAlex records an abstract for this work, but it could not be fetched just now.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.092
metaresearch head score (Gemma)0.096
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Meta-analysis · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.092
Threshold uncertainty score0.489

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0920.096
Meta-epidemiology (narrow)0.0020.002
Meta-epidemiology (broad)0.0050.013
Bibliometrics0.0020.003
Science and technology studies0.0010.002
Scholarly communication0.0020.001
Open science0.0030.002
Research integrity0.0020.002
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.111
GPT teacher head0.377
Teacher spread0.266 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designMeta-analysis
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1,053
Published2013
Admission routes2
Has abstractyes

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