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Record W2119310382 · doi:10.1086/655826

The Present and Future Control of Pertussis

2010· letter· en· W2119310382 on OpenAlexaboutno aff
James D. Cherry

Bibliographic record

VenueClinical Infectious Diseases · 2010
Typeletter
Languageen
FieldImmunology and Microbiology
TopicBacterial Infections and Vaccines
Canadian institutionsnot available
FundersSanofi PasteurGlaxoSmithKline
KeywordsMedicineWhooping coughMEDLINEBordetella pertussisIntensive care medicineVirologyVaccination

Abstract

fetched live from OpenAlex

(See the article by Mertsola et al, on pages 656–662.) Currently, there are 2 tetanus and reduced antigen content diphtheria and acellular pertussis vaccines (Tdap vaccines; called dTpa in Europe) available for the immunization of older children, adolescents, and adults [1]. These vaccines are Boostrix produced by GlaxoSmithKline Biologicals and Adacel produced by Sanofi Pasteur. These vaccines are approved in the United States for only 1 booster dose in older children, adolescents, and adults (Boostrix for those ages 10–64 years and Adacel for those ages 11–64 years). However, because booster doses of diphtheria and tetanus toxoids are currently recommended for decennial administration, it is assumed by most pertussis vaccine and public health experts that after additional studies Tdap will be approved for routine booster doses at 10-year intervals. In this issue of Clinical Infectious Diseases, Mertsola et al [2] examine the immunogenicity and reactogenicity profile of Tdap after a second decennial dose in young adults.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.004
metaresearch head score (Gemma)0.006
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Editorial · Consensus signal: none
Teacher disagreement score0.056
Threshold uncertainty score0.187

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0040.006
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.001
Scholarly communication0.0030.003
Open science0.0010.002
Research integrity0.0050.004
Insufficient payload (model declined to judge)0.0560.016

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.294
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEditorial

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations118
Published2010
Admission routes1
Has abstractyes

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