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Record W2119328661 · doi:10.1136/ebm.11.5.149

Calcium did not prevent fractures in elderly women

2006· letter· en· W2119328661 on OpenAlexaff
S. A Jamal

Bibliographic record

VenueEvidence-Based Medicine · 2006
Typeletter
Languageen
FieldMedicine
TopicBone health and osteoporosis research
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsMedicinePlaceboPopulationAmbulatoryPediatricsSurgery

Abstract

fetched live from OpenAlex

Prince RL, Devine A, Dhaliwal SS, et al. Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Arch Intern Med 2006;166:869–75. [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q In ambulatory elderly women unselected for low bone mass, does calcium supplementation reduce the risk of fractures? Clinical impact ratings GP/FP/Primary care ★★★★★☆☆ Public health ★★★★★★☆ Geriatrics ★★★★★☆☆ ### ![Graphic][5] Design: randomised, placebo controlled trial. ### ![Graphic][6] Allocation: concealed.* ### ![Graphic][7] Blinding: blinded {patients, healthcare providers, data collectors, and outcome assessors}†.* ### ![Graphic][8] Follow up period: 5 years. ### ![Graphic][9] Setting: population-based study in Western Australia. ### ![Graphic][10] Participants: 1460 ambulatory women >70 years of age (mean age 75 y) who were not taking any medication affecting bone mass and were expected to survive >5 years. ### ![Graphic][11] Intervention: calcium carbonate, 600 mg twice daily with meals (n = 730), or placebo (n = 730). ### ![Graphic][12] Outcomes: incident atraumatic clinical fractures and symptomatic vertebral fractures (self reported and confirmed by radiographic reports), and adverse events requiring medical attention. … [1]: {openurl}?query=rft.jtitle%253DArchives%2Bof%2BInternal%2BMedicine%26rft.stitle%253DArch%2BIntern%2BMed%26rft.issn%253D0003-9926%26rft.aulast%253DPrince%26rft.auinit1%253DR.%2BL.%26rft.volume%253D166%26rft.issue%253D8%26rft.spage%253D869%26rft.epage%253D875%26rft.atitle%253DEffects%2Bof%2BCalcium%2BSupplementation%2Bon%2BClinical%2BFracture%2Band%2BBone%2BStructure%253A%2BResults%2Bof%2Ba%2B5-Year%252C%2BDouble-blind%252C%2BPlacebo-Controlled%2BTrial%2Bin%2BElderly%2BWomen.%26rft_id%253Dinfo%253Adoi%252F10.1001%252Farchinte.166.8.869%26rft_id%253Dinfo%253Apmid%252F16636212%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1001/archinte.166.8.869&link_type=DOI [3]: /lookup/external-ref?access_num=16636212&link_type=MED&atom=%2Febmed%2F11%2F5%2F149.atom [4]: /lookup/external-ref?access_num=000237026000006&link_type=ISI [5]: /embed/inline-graphic-1.gif [6]: /embed/inline-graphic-2.gif [7]: /embed/inline-graphic-3.gif [8]: /embed/inline-graphic-4.gif [9]: /embed/inline-graphic-5.gif [10]: /embed/inline-graphic-6.gif [11]: /embed/inline-graphic-7.gif [12]: /embed/inline-graphic-8.gif

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Direct model labels (unvalidated)

Per-model category and study-design labels from the labeling rounds. They are machine output, unvalidated, and the disagreement between models ships as data. No study design here is MEDLINE-validated yet.

Model armCategoriesStudy designConfidence
gemmano category
Domain: not available · Genre: Commentary
About the Canadian research system: no · About a Canadian topic: no
Observationallow
gptno category
Domain: not available · Genre: Commentary
About the Canadian research system: no · About a Canadian topic: no
Randomized triallow
models splitAgreement compares identical category sets and study designs across arms.

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Commentary · Consensus signal: none
Teacher disagreement score0.013
Threshold uncertainty score0.045

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.005
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.002
Bibliometrics0.0010.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.0130.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.073
GPT teacher head0.385
Teacher spread0.312 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Labeled directly by 2 models reading the full record.

The models applied no category: nothing in the taxonomy fit this work.

The models disagree on parts of this classification; every voice is preserved in the section at the end of the page.

Study designObservational · Randomized trial
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2006
Admission routes1
Has abstractyes

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