Inclusion Criteria Based on DAS28 Score: Strength of Improvement Is Less Dependent on Baseline Disease Activity Than Expected
Bibliographic record
Abstract
In the past decade much effort was directed toward the lowering of disease activity in patients with rheumatoid arthritis (RA) and the most optimal disease state: remission. The word “remission” is commonly used in oncology to define a health condition in which the signs and presence of malignant disease are absent after treatment. The fact that treatment of RA has also become more and more effective by starting therapy early in the disease, combining disease-modifying antirheumatic drugs and the use of biologicals, has stimulated rheumatologists to aim for remission as well. However, in contrast to a number of malignancies, RA can seldom be “cured” and most patients show relapse after stopping treatment1,2. Therefore, the aim of treatment in RA is directed toward a low disease activity state, most often defined as a Disease Activity Score 28 (DAS28) < 3.2 and the threshold … Address correspondence to Dr. van der Horst-Bruinsma; E-mail: ie.vanderhorst{at}vumc.nl
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.011 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.007 | 0.003 |
| Insufficient payload (model declined to judge) | 0.013 | 0.008 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".