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Record W2119846684 · doi:10.1074/jbc.x400010200

My Brief Encounter with the Phosphoinositides and IP3

2004· article· en· W2119846684 on OpenAlexaboutno aff
Clinton E. Ballou

Bibliographic record

VenueJournal of Biological Chemistry · 2004
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicMetabolism and Genetic Disorders
Canadian institutionsnot available
Fundersnot available
KeywordsHobbyChemistryMonosaccharideCarbohydrate chemistryChemistLibrary scienceOrganic chemistryComputer sciencePolitical scienceLaw

Abstract

fetched live from OpenAlex

For my first independent research project after my appointment to the Berkeley faculty, I chose to work on the structures of myoinositol-containing phospholipids, a study that led us eventually to the discovery of d-myoinositol 1,4,5-trisphosphate or IP3. Before describing this research, however, I should say how that choice came about. While in graduate school at the University of Wisconsin, I had had the good fortune to study under Karl Paul Link, who was widely renowned for his discovery of dicumarol and the synthesis of related blood anticoagulants such as warfarin, work that was recognized with two Lasker Awards (1).

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.004
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Commentary · Consensus signal: none
Teacher disagreement score0.021
Threshold uncertainty score0.069

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.004
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.003
Science and technology studies0.0050.002
Scholarly communication0.0060.007
Open science0.0010.004
Research integrity0.0060.010
Insufficient payload (model declined to judge)0.0210.015

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.214
Teacher spread0.207 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreCommentary

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations4
Published2004
Admission routes1
Has abstractyes

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